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Penetanguishene Commercial Property for Rent

Showing results 1 - 13 of 13

In Penetanguishene, the commercial rental market is on the rise, offering diverse opportunities for businesses. Square Yards Canada simplifies your search for the perfect commercial for rent in Penetanguishene. Our platform provides a seamless experience with easy-to-use filters for property type, price range, size, and amenities. Start by selecting your desired property type, whether it's retail space or Penetanguishene commercial for rent. Refine your search by adjusting price and size to meet your needs. The listings can be sorted by newness or price to find the best options. Explore our Penetanguishene commercial for rent listings today and find the perfect space to grow your business.

Last Updated: August 06, 2026

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101 Main Street, Simcoe, ON , MLS #S13515134 , Image - 1

Unit-2, 101 Main Street Penetanguishene, Simcoe, ON MLS® S13515134

Commercial (Commercial Retail)

$1500.0

2 Baths

*Parking and Utilities Included* Excellent commercial lease opportunity in the heart of downtown Penetanguishene, offering a spacious open-concept lay

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101 Main Street, Simcoe, ON , MLS #S13515112 , Image - 1

Unit-1, 101 Main Street Penetanguishene, Simcoe, ON MLS® S13515112

Commercial (Commercial Retail)

$1600.0

1 Baths

* Parking and Utilities Included* Fantastic commercial lease opportunity with Main Street frontage in the heart of downtown Penetanguishene. Positione

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101 Main Street, Simcoe, ON , MLS #S13450354 , Image - 1

101 Main Street Penetanguishene, Simcoe, ON MLS® S13450354

Commercial (Commercial Retail)

$2500.0

2 Baths

<<<3 PARKING SPACES INCLUDED>>> Fantastic commercial lease opportunity in the heart of downtown Penetanguishene. Situated at a high-visibility corner

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200A Main Street, Simcoe, ON , MLS #S12578666 , Image - 1

200A Main Street Penetanguishene, Simcoe, ON MLS® S12578666

Commercial (Commercial Retail)

Price On Request

Nestled prominently at the intersection of Main Street and Thompsons Road, this upcoming freestanding building presents an exciting prospect for redef

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68 Main Street, Simcoe, ON , MLS #S12865040 , Image - 1

68 Main Street Penetanguishene, Simcoe, ON MLS® S12865040

Commercial (Commercial Retail)

$1100.0

Prime commercial space available in the heart of downtown Penetanguishene. Located at 68 Main Street, this approximately 398 sq ft unit offers excelle

40 Photos

101 Main St, Simcoe, Ontario , MLS #S11979035 , Image - 1

101 Main St Penetanguishene, Simcoe, ON MLS® S11979035

Commercial (Commercial/Retail)

$2400.0

This commercial space in downtown Penetanguishene offers an exceptional opportunity for businesses seeking great value and convenience. Inclusive of t

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118 Main St, Simcoe, Ontario , MLS #S11973393 , Image - 1

118 Main St Penetanguishene, Simcoe, ON MLS® S11973393

Commercial (Commercial/Retail)

$2000.0

Prime commercial space in a historic building right beside Shoppers Drug Mart with waterfront access in walking distance. Ample parking at the side of

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102 Main St, Simcoe, Ontario , MLS #S10420920 , Image - 1

102 Main St Penetanguishene, Simcoe, ON MLS® S10420920

Commercial (Commercial/Retail)

$1800.0

Reduced by 5.3%

Excellent location 900 sqft commercial unit for lease on Main Street in Penetanguishene. CG zoning allows for many commercial uses. All in a high traf

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200 Main St, Simcoe, Ontario , MLS #S8480998 , Image - 1

Unit-2, 200 Main St Penetanguishene, Simcoe, ON MLS® S8480998

Commercial (Commercial/Retail)

Price On Request

Situated at the apex of Main Street, this forthcoming commercial space promises to redefine the landscape of business in our vibrant town. Boasting a

2 Photos

200 Main St, Simcoe, Ontario , MLS #S8480996 , Image - 1

Unit-1, 200 Main St Penetanguishene, Simcoe, ON MLS® S8480996

Commercial (Commercial/Retail)

Price On Request

Situated at the apex of Main Street, this forthcoming commercial space promises to redefine the landscape of business in our vibrant town. Boasting a

2 Photos

200A Main St, Simcoe, Ontario , MLS #S8480994 , Image - 1

200A Main St Penetanguishene, Simcoe, ON MLS® S8480994

Commercial (Commercial/Retail)

Price On Request

Nestled prominently at the intersection of Main Street and Thompsons Road, this upcoming freestanding building presents an exciting prospect for redef