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Commercial Property for Rent in Guelph South Guelph

Showing results 1 - 30 of 40

Find an extensive selection of commercial for rent in Guelph South, Guelph on Square Yards Canada. This lively community presents modern amenities like visitor parking, security systems, and fitness centres, tailored to various business needs. Our user-friendly advanced filters enable you to refine your search by property type, price range, size, and specific features, such as the number of bathrooms and age of the property. Guelph South commercial for rent options are ideal for its strong infrastructure and excellent connectivity, making it an ideal location for your business expansion. Kickstart your search today for the perfect commercial for lease in Guelph South, Guelph.

Last Updated: December 05, 2025

1 Photos

Unit-2, 935A Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40748054

Commercial Lease (Industrial,Building Only)

Price On Request

10559 sq-ft

Immaculate Industrial Unit Located in the Prestigious Hanlon Creek Business Park. Modern State-of-the-Art Construction with 24' Clear Height, ESFR Spr

15 Photos

18 Wilson Street, Wellington, ON , MLS #40745234 , Image - 1

Unit-B, 18 Wilson Street Guelph South, Guelph, Wellington, ON MLS® 40745234

Commercial Lease (Office,Building Only)

$3000

1100 sq-ft

Unit B offers a functional ±1,100 SF two-storey office space, located on the second and third floors. The layout includes a mix of open areas, private

11 Photos

85 Norfolk Street, Wellington, ON , MLS #40743167 , Image - 1

Unit-202, 85 Norfolk Street Guelph South, Guelph, Wellington, ON MLS® 40743167

Commercial Lease (Office,Building Only)

Price On Request

908 sq-ft

Large office available at Norfolk Medical Centre. Sound proof office. Professionally managed. Minutes to downtown Guelph. Landlord willing to renovate

12 Photos

85 Norfolk Street, Wellington, ON , MLS #40743162 , Image - 1

Unit-201, 85 Norfolk Street Guelph South, Guelph, Wellington, ON MLS® 40743162

Commercial Lease (Office,Building Only)

Price On Request

1417 sq-ft

Large office available at Norfolk Medical Centre. Sound proof office. Professionally managed. Minutes to downtown Guelph. Landlord willing to renovate

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Unit-303, 85 Norfolk Street Guelph South, Guelph, Wellington, ON MLS® 40743176

Commercial Lease (Office,Building Only)

Price On Request

911 sq-ft

Large office available at Norfolk Medical Centre. Sound proof office. Professionally managed. Minutes to downtown Guelph. Landlord willing to renovate

9 Photos

35 Wyndham Street N, Wellington, ON , MLS #40742291 , Image - 1

35 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40742291

Commercial Lease (Retail,Building Only)

$4995

2005 sq-ft

2005 SF ground-floor retail space with a basement, available for possession on August 1, 2025. Located in a busy commercial district, this property of

5 Photos

49 Cork Street E, Wellington, ON , MLS #40738461 , Image - 1

49 Cork Street E Guelph South, Guelph, Wellington, ON MLS® 40738461

Commercial Lease (Retail,Building Only)

$2655

1043 sq-ft

1043 sf retail space available for lease. Centrally located downtown Guelph, 49 Cork St E is an excellent opportunity for business owners looking to o

2 Photos

55 Wyndham Street N, Wellington, ON , MLS #40726980 , Image - 1

Unit-T4B, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40726980

Commercial Lease (Mixed,Building Only)

Price On Request

770 sq-ft

Excellent retail unit in downtown Guelph's Old Quebec Street City Centre. Be part of the vibrant downtown core. All unit numbers, sizes and locations

2 Photos

55 Wyndham Street N, Wellington, ON , MLS #40726912 , Image - 1

Unit-217A, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40726912

Commercial Lease (Mixed,Building Only)

Price On Request

792 sq-ft

Excellent retail unit in downtown Guelph's Old Quebec Street City Centre. Be part of the vibrant downtown core. All unit numbers, sizes and locations

11 Photos

55 Cork Street, Wellington, ON , MLS #40722210 , Image - 1

Unit-101, 55 Cork Street Guelph South, Guelph, Wellington, ON MLS® 40722210

Commercial Lease (Retail,Building Only)

Price On Request

2301 sq-ft

Exceptional lease opportunity in downtown Guelph. This retail space, situated in a 3-storey building, offers 2,301 SF. Zoned as Specialized Downtown,

5 Photos

19-21 Gordon Street, Wellington, ON , MLS #40717081 , Image - 1

Unit-Main, 19-21 Gordon Street Guelph South, Guelph, Wellington, ON MLS® 40717081

Commercial Lease (Retail,Building Only)

Price On Request

4279 sq-ft

Rare opportunity to lease a high profile office / retail space along Gordon street. 21 Gordon is located just south of the downtown core and close to

5 Photos

19-21 Gordon Street, Wellington, ON , MLS #40717065 , Image - 1

Unit-2, 19-21 Gordon Street Guelph South, Guelph, Wellington, ON MLS® 40717065

Commercial Lease (Retail,Building Only)

Price On Request

1952 sq-ft

Rare opportunity to lease a high profile office / retail space along Gordon street. 21 Gordon is located just south of the downtown core and close to

5 Photos

935 Southgate Drive, Wellington, ON , MLS #40713053 , Image - 1

Unit-A3, 935 Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40713053

Commercial Lease (Warehouse,Building Only)

Price On Request

17554 sq-ft

An excellent opportunity to sub-lease a 17,554 sf warehouse unit located on Southgate Drive in Guelph. This modern industrial space features 28 ft cle

1 Photos

Unit-T20, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40711195

Commercial Lease (Retail,Building Only)

Price On Request

1473 sq-ft

Excellent retail unit in downtown Guelph's Old Quebec Street City Centre. Be part of the vibrant downtown core. All unit numbers, sizes and locations

1 Photos

Unit-T11B, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40711159

Commercial Lease (Retail,Building Only)

Price On Request

1650 sq-ft

Excellent retail unit in downtown Guelph's Old Quebec Street City Centre. Be part of the vibrant downtown core. All unit numbers, sizes and locations

1 Photos

Unit-T11A, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40711151

Commercial Lease (Retail,Building Only)

Price On Request

1650 sq-ft

Excellent retail unit in downtown Guelph's Old Quebec Street City Centre. Be part of the vibrant downtown core. All unit numbers, sizes and locations

1 Photos

Unit-T11C, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40711185

Commercial Lease (Retail,Building Only)

Price On Request

1650 sq-ft

Excellent retail unit in downtown Guelph's Old Quebec Street City Centre. Be part of the vibrant downtown core. All unit numbers, sizes and locations

1 Photos

Unit-T11, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40711140

Commercial Lease (Retail,Building Only)

Price On Request

4961 sq-ft

Excellent retail unit in downtown Guelph's Old Quebec Street City Centre. Be part of the vibrant downtown core. All unit numbers, sizes and locations

1 Photos

Unit-C, 19 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40708989

Commercial Lease (Office,Building Only)

Price On Request

1079 sq-ft

1,079 sq ft of Impressive 2nd floor “funky” one of a kind office space in downtown Guelph’s historic Petrie Building. fully assessable with elevator,

6 Photos

1080 Southgate Drive, Wellington, ON , MLS #40688578 , Image - 1

Unit-2, 1080 Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40688578

Commercial Lease (Industrial,Building and Land)

Price On Request

186010 sq-ft

Developed by Panattoni and targeting LEED certification, 1080 Southgate Drive is a brand new Class A industrial development located in Guelph's Southg

6 Photos

1080 Southgate Drive, Wellington, ON , MLS #40688580 , Image - 1

Unit-1, 1080 Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40688580

Commercial Lease (Industrial,Building and Land)

Price On Request

115717 sq-ft

Developed by Panattoni and targeting LEED certification, 1080 Southgate Drive is a brand new Class A industrial development located in Guelph's Southg

6 Photos

1080 Southgate Drive, Wellington, ON , MLS #40688550 , Image - 1

Unit-Full Bldg, 1080 Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40688550

Commercial Lease (Industrial,Building and Land)

Price On Request

444186 sq-ft

Developed by Panattoni and targeting LEED certification, 1080 Southgate Drive is a brand new Class A industrial development located in Guelph's Southg

6 Photos

1080 Southgate Drive, Wellington, ON , MLS #40688574 , Image - 1

Unit-3, 1080 Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40688574

Commercial Lease (Industrial,Building and Land)

Price On Request

256303 sq-ft

Developed by Panattoni and targeting LEED certification, 1080 Southgate Drive is a brand new Class A industrial development located in Guelph's Southg

6 Photos

1080 Southgate Drive, Wellington, ON , MLS #40688571 , Image - 1

Unit-4, 1080 Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40688571

Commercial Lease (Industrial,Building and Land)

Price On Request

350022 sq-ft

Developed by Panattoni and targeting LEED certification, 1080 Southgate Drive is a brand new Class A industrial development located in Guelph's Southg

5 Photos

264 Crawley Road, Wellington, ON , MLS #40674939 , Image - 1

264 Crawley Road Guelph South, Guelph, Wellington, ON MLS® 40674939

Commercial Lease (Office,Building Only)

Price On Request

3032 sq-ft

Historic home, renovated and rezoned ready for an office or medical office tenant. The Crawley farmhouse – once known as “Willowgrove” and more recent

4 Photos

98 Macdonell Street, Wellington, ON , MLS #40600664 , Image - 1

98 Macdonell Street Guelph South, Guelph, Wellington, ON MLS® 40600664

Commercial Lease (Office,Building Only)

Price On Request

6800 sq-ft

98 Macdonell offers 6,800 sq. ft. of high-profile professional office space in the heart of downtown Guelph. The available space is fully furnished an

2 Photos

945A Southgate Drive, Wellington, ON , MLS #40581748 , Image - 1

945A Southgate Drive Guelph South, Guelph, Wellington, ON MLS® 40581748

Commercial Lease (Industrial,Building Only)

Price On Request

29973 sq-ft

Immaculate Industrial Unit Located in the Prestigious Hanlon Creek Business Park. Modern State-of-the-Art Construction with 24' Clear Height, ESFR Spr

1 Photos

Unit-212, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 40523796

Commercial Lease (Mixed,Building Only)

Price On Request

12904 sq-ft

This 12,904 SF unit includes a number of private offices. Should you require more space, the Landlord is prepared to expand with another 12,912 SF con

1 Photos

27 Quebec Street Guelph South, Guelph, Wellington, ON MLS® 40494574

Commercial Lease (Retail,Building Only)

Price On Request

2149 sq-ft

2,149 sq ft, Ground floor retail space, former florist, coolers still in place, immediate occupancy, good signage, ideal for many uses, 618 sq. ft. me

1 Photos

Unit-202, 55 Wyndham Street N Guelph South, Guelph, Wellington, ON MLS® 30782486

Commercial Lease (Office,Building Only)

Price On Request

1680 sq-ft

1680 SF office space available in the Old Quebec Street Centre in downtown Guelph. Lots of amenities in the area. Property can be demised to suit your

Shortlisted Properties

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